“Art is the food for madness.”

Stourley Kracklite, a driven, detail-obsessed architect, travels from America to Rome with his much younger wife, Louisa, to oversee an architectural homage to a personal hero, 18th-century master builder Etienne-Louis Boullée. En route by train, Stourley and Louisa conceive a much-wanted child — but Stourley's obsession with his wife's expanding belly, her perceived infidelity, and his own recurrent bouts of abdominal pain reach epic and dangerous proportions.